The scientific interests in the Vertes Research Group span from fundamental studies in analytical and physical chemistry to the development of new technologies for biomedical analysis. Recent accomplishments include the discovery of photonic ion sources based on columnar nanostructures, the introduction of a new ambient ion source called laser ablation electrospray ionization (LAESI), metabolic imaging of biological tissues under native conditions and the in situ mass spectrometric analysis of single cells.
The Office of Media Relations at GW on June 17, 2015, issued a press release entitled “Detecting the Undetectable: New Chip Identifies Chemicals in Ultratrace Amounts.” It describes some potential applications of the recently commercialized REDIchip technology developed in our laboratory. The release was picked up by EurekAlert!, Phys.Org and other web portals
On June 1, 2015, Protea Biosciences Group, Inc., issued a press release about the commercial availability of a new mass spectrometry technology dubbed REDIchip. The REDI acronym stands for “resonance-enhanced desorption ionization” referring to a nanophotonic ionization property of the silicon nanopost array (NAPA) incorporated in the device. Numerous media outlets, including CNN Money, Yahoo Finance and GlobeNewswire carried the story.
On March 9, 2015, Protea Biosciences, Inc., issued a press release describing the introduction of a new product marketed under the REDIchip name. This ultrasensitive platform for laser desorption ionization mass spectrometry is based on the silicon nanopost array (NAPA) technology developed in the Vertes laboratory.
In the March, 2015, Supplement to Chemical & Engineering News dedicated to advances in chromatography, mass spectrometry and lab automation, our article entitled "High-Throughput Cell and Tissue Analysis with Enhanced Molecular Coverage by Laser Ablation Electrospray Ionization Mass Spectrometry Using Ion Mobility Separation" (Anal. Chem., 2014, 86, 4308–4315) was selected by the Editors among the ten most notable papers within these fields published last year in Analytical Chemistry.
Vertes Victories. On August 13, 2014, in a flattering piece entitled “Vertes Victories,” John DiConsiglio, a news writer for the Columbian College of Arts and Sciences, discussed my professional career and future plans. A more appropriate title for this article would have been “Vertes Group Victories,” as these achievements reflect the work of many talented associates.
Construction of Science and Engineering Hall nears completion. In the first week of August, 2014, we received the relocation schedule to move our laboratories and offices to the SEH building. This ambitious plan allocates 5 days for moving our offices and 38 days, mostly January of 2015, to move my laboratories. You can follow the phases of the above-ground construction through our photo diary.
Inducted members of the National Academy of Inventors on congressional record. On 2-11-2014, the Hon. Kathy Castor, Representative of Florida, read the names of the newly inducted members of the National Academy of Inventors into the Congressional Record. Dr. Akos Vertes was elected as a Fellow in December 2013.
Physics Today article features LAESI and the Vertes Group. On 1-30-2013, David Lindley published an article in Physics Today entitled "Lasers make biological assays easier" that described our work dedicated to the analysis of biological cells and tissues.
Vertes Group featured in "Educating Inventors at GW " video. On 1-29-2013, a video entitled "Educating Inventors at GW" appeared on YouTube featuring the Vertes Group. In this video, Dr. Vertes discusses student participation in the development of new technologies and creating intellectual property.
High school student Pranav Balan gave an oral presentation at the 63-rd ASMS Conference on Mass Spectrometry and Allied Topics in St. Louis, MO. Pranav is a student of the Thomas Jefferson High School for Science and Technology in Alexandria, VA. As a rising senior, he participated in summer internship in the Vertes laboratory. During the fall of 2014, he continued in the mentorship program to fully develop his project. The oral presentation entitled "Molecular Imaging of Antibiotic Inhibition of Bacterial Growth and Metabolism by Laser Ablation Electrospray Ionization Mass Spectrometry" on June 2, 2015, was the culmination of his participation.
On May 18, 2015, we learned that Linwen Zhang was selected by the Washington-Baltimore Mass Spectrometry Discussion Group to receive a Young Investigator Travel Award to attend the 63-rd annual conference of the American Society for Mass Spectrometry in St. Louis, MO. Linwen's presentation was entitled "Metabolic Analysis of Single Human Cells by Capillary Microsampling Electrospray Ionization Mass Spectrometry and Stable Isotope Labeling."
On March 11, 2015, Sylwia Stopka was selected as an Achievement Rewards for College Scientists (ARCS) scholar for 2015-2016 by the Metropolitan Washington Chapter of the ARCS Foundation. This prestigious award supports Sylwia's work to develop new technologies for the rapid analysis of metabolites in microbial cell populations by LAESI mass spectrometry, and the imaging of metabolite and lipid distributions in mammalian tissues by laser desorption ionization from NAPA.
Update: On June 15, 2015, we learned that Sylwia was selected as the 2015-2016 Danaher Corporation Scholar.
1-30-2015 Congratulations to Amy Li and Sylwia Stopka on receiving MSCAL 2015 US Young Investigator Travel Grants. These grants help them to attend the 2015 Mass Spectrometry: Applications to the Clinical Lab Conference, where Amy's contribution entitled "Three-dimensional Metabolic Imaging of Live Bacterial Colonies by Laser Ablation Electrospray Ionization Mass Spectrometry with Ion Mobility Separation" is selected for a podium presentation. Sylwia presents a poster on "High Throughput Pulse-chase Analysis of Metabolite Turnover in Microorganisms Followed by LAESI Mass Spectrometry."
Sylwia Stopka receives a 2014 MSDG Young Investigator Travel Award. On 5-19-2014, the Washington-Baltimore Mass Spectrometry Discussion Group selected Sylwia Stopka, a graduate student in the group, for a travel award. The financial component of the award helped her to attend the 62-nd ASMS Conference on Mass Spectrometry and Allied Topics in Baltimore, MD, where she gave an oral presentation entitled "Metabolic Response to Altered Light Conditions in Genetically Modified Chlamydomonas by LAESI Mass Spectrometry with Ion Mobility Separation."
First and second prize in Undergraduate Natural Sciences at GW Research Days. On 4-1-2014, undergraduate students Emmeline Ha and Daniel Foreman swept the Undergraduate Natural Sciences: Cellular/Molecular category at the GW Research Days 2014. Emmeline's first place poster was titled "Revealing the binding properties behind copper(II)’s anti-aggregative effect on human amylin," whereas Dan placed second with his poster "Comparative Metabolic Profiling of Single Plant Cells by Capillary Microsampling and Electrospray Ionization Mass Spectrometry."
Prof. Vertes elected Fellow of the National Academy Inventors. On 12-11-2013, GW Today reported on Dr. Akos Vertes' election as a Fellow of the National Academy of Inventors. On December 18, 2013, this was followed by a GW press release through Newswise.
155/ Hang Li, Pranav Balan, and Akos Vertes, “Molecular Imaging of Growth, Metabolism, and Antibiotic Inhibition in Bacterial Colonies by Laser Ablation Electrospray Ionization Mass Spectrometry,” Angew. Chem. Int. Ed., 2016, 55, 15035 –15039.
154/ Andrew R. Korte, Sylwia A. Stopka, Nicholas Morris, Trust Razunguzwa, and Akos Vertes, “Large-Scale Metabolite Analysis of Standards and Human Serum by Laser Desorption Ionization Mass Spectrometry from Silicon Nanopost Arrays,” Anal. Chem., 2016, 88, 8989-8996.
153/ Sylwia A. Stopka, Charles Rong, Andrew R. Korte, Sridevi Yadavilli, Javad Nazarian, Trust T. Razunguzwa, Nicholas J. Morris, and Akos Vertes, “Molecular Imaging of Biological Samples on Nanophotonic Laser Desorption Ionization Platforms,” Angew. Chem. Int. Ed., 2016, 55, 4482-4486.
152/ Sylwia A. Stopka, Tarek R. Mansour, Bindesh Shrestha, Eric Marechal, Denis Falconet and Akos Vertes, “Turnover Rates in Microorganisms by LAESI Mass Spectrometry and Pulse-chase Analysis,” Anal. Chim. Acta, 2016, 902, 1-7.
151/ Rachelle S. Jacobson, Richard Thurston, Bindesh Shrestha, and Akos Vertes, “In Situ Analysis of Small Populations of Adherent Mammalian Cells Using Laser Ablation Electrospray Ionization Mass Spectrometry in Transmission Geometry,” Anal. Chem., 2015, 87, 12130-12136.
150/ Linwen Zhang and Akos Vertes, “Energy Charge, Redox State and Metabolite Turnover in Single Human Hepatocytes Revealed by Capillary Microsampling Mass Spectrometry,” Anal. Chem., 2015, 87, 10397-10405.
149/ Hang Li, Emmeline Ha, Robert P. Donaldson, Aleksandar M. Jeremic and Akos Vertes, “Rapid Assessment of Human Amylin Aggregation and its Inhibition by Copper(II) Ions by Laser Ablation Electrospray Ionization Mass Spectrometry with Ion Mobility Separation,” Anal. Chem., 2015, 87, 9829-9837.
148/ Nicholas J. Morris, Heather Anderson, Brian Thibeault, Akos Vertes, Matthew J. Powell and Trust T. Razunguzwa, “Laser desorption ionization (LDI) silicon nanopost array chips fabricated using deep UV projection lithography and deep reactive ion etching,” RSC Advances, 2015, 5, 72051–72057.
147/ Rohit Shroff, Katharina Schramm, Verena Jeschke, Peter Nemes, Akos Vertes, Jonathan Gershenzon and Ales Svatos, “Quantification of plant surface metabolites by MALDI mass spectrometry imaging: glucosinolates on Arabidopsis thaliana leaves,” The Plant Journal, 2015, 81, 961-972.
146/ Laine R. Compton, Brent Reschke, Jordan Friend, Matthew Powell and Akos Vertes, “Remote Laser Ablation Electrospray Ionization Mass Spectrometry for Non-proximate Analysis of Biological Tissues,” Rapid Commun. Mass Spectrom., 2015, 29, 67-73.
145/ Hang Li, Brian K. Smith, Laszlo Mark, Peter Nemes, Javad Nazarian, and Akos Vertes, “Ambient Molecular Imaging by Laser Ablation Electrospray Ionization Mass Spectrometry with Ion Mobility Separation,” Int. J. Mass Spectrom., 2015, 375, 681-689.
A Conversation with Dean Ben Vinson III - December 9, 2014, ~8 min
TECHNOLOGY INNOVATION AT GW - A Success Story - July 12, 2014, ~4 min
TECHNOLOGY TRANSFER - A Story of Success - January 25, 2014, ~3 min